CHEM G4210y. Writing Workshop for Chemists. 1 pt. Prerequisites: Recommended for undergraduate students to have taken at least one semester of independent research.

This course offers undergraduate and graduate students an introduction to scientific writing and provides an opportunity for them to become more familiar with the skill and craft of communicating complex scientific research. This course will provide students with the basic grammatical, stylistic and practical skills required to write effective academic journal articles, theses, or research proposals. In addition, through an innovative partnership with Columbia University Libraries' Digital Science Center, students will learn how to apply these basic skills to their writing through the use of state-of-the-art software and online resources. Regular opportunities to write, peer edit and revise throughout the semester will allow students to put what they are learning into immediate practice. It is recommended that undergraduates have taken at least one semester of research for credit before taking this course. Undergraduates should plan to take this course after taking the required Core course University Writing.

CHEM G9303x-G9303y (Section 1). Investigation of Special Problems in Chemistry. 1-12 pts. Points to be arranged. Not offered in 2013-2014.

Individualized research projects.

CHEM G9307x-G9307y (Section 1). Research for the Doctorate. 1-12 pts. Pass/Fail

Department's permission.

CHEM G4145y. NMR Spectroscopy. 1 pt. Prerequisites: Elementary organic chemistry.

Introduction to theory and practice of NMR spectroscopy. Instrumental aspects, basic NMR theory, NOE, and a survey of 2D methods are covered.

CHEM G4147x. Advanced Organic Chemistry. 4.5 pts. Prerequisites: Elementary organic and physical chemistry.

The mechanisms of organic reactions, structure of organic molecules, and theories of reactivity. How reactive intermediates are recognized and mechanisms are deduced using kinetics, stereochemistry, isotopes, and physical measurements.

CHEM G4148x. Synthetic Methods in Organic Chemistry I. 4.5 pts.

Construction, analysis and strategies for the synthesis of complex natutal products.

CHEM G4168x. Materials Chemistry I. 4.5 pts. Prerequisites: Sophomore Organic and Inorganic Chemistry

This course will have two main themes. One theme will explore the design, synthesis, and properties of materials made from molecules. Topics that will be covered in this section of the course include the chemistry of liquid crystals, self-assembled monolayers, organic electronics, carbon-based nanostructures, self-assembled materials, and bio-inspired materials. A second theme will explore inorganic materials. It will compare the chemistry of chemical vapor deposition and vapor phase epitaxy to make solid state materials. It will further study the transformation from chemical bonds to solid-state band structure in materials and quantum size effects.

CHEM G4172y. Biorganic Topics. 4.5 pts. Prerequisites: Elementary organic chemistry.

Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosysnthesis of natural products and some other bioorganic topics.

BIOC W4312x. Chemical Biology. 4 pts. Prerequisites: Elementary organic chemistry CHEM C3443, CHEM C3444. Recommended preparation elementary physical chemistry and biochemistry CHEM C3079 CHEM C3080.

Development and application of chemical methods for understanding the molecular mechanisms of cellular processes. Review of the biosynthesis, chemical synthesis, and structure and function of proteins and nucleic acids. Application of chemical methods--including structural biology, enzymology, chemical genetics, and the synthesis of modified biological molecules--to the study of cellular processes--including transcription, translation, and signal transduction.

CHEM G8120y. Polymers in Nanotechnology. 2.5 pts. Prerequisites: N/A Corequisites: N/A

Polymeric materials have long been ubiquitous items and played important roles in revolutionizing the way we live. Due to the advent of modern polymerization fabrication strategies, polymers are rapidly gaining interest for the development of next generation devices and medical treatment. This course will focus on the chemistry polymers and their use as nanostructured materials created by self-assembly and top-down fabrication techniques. Specifically, the class will be divided into two sections describing the uses of organic nanostructures on a) surfaces and b) as particles. Patterned surfaces will be described in terms of photo-, imprint-, and block copolymer lithography. The preparation of nanoparticles through polymer synthesis, dendrimers, and mechanical manipulation will be the second part.

CHEM G8149y. Synthetic Methods in Organic Chem. II. 4.5 pts. Prerequisites:CHEM G8148.

Construction, analysis, and strategies for the synthesis of complex natural products.

CHEM G8310y. Transition Metals in Organic Synthesis. 2.5 pts. Not offered in 2013-2014.

Recent advances in the development of homogeneous catalysis for selective organic synthesis. Emphasis on both mechanistic and synthetic aspects.

CHEM G8311x. Natural Products Chemistry. 2.5 pts. Not offered in 2013-2014.

Topics from recent trends in natural products chemistry, especially in ligand/receptor interactions.

CHEM G8313x. Modern Molecular Photochemistry of Organic Compounds. 2.5 pts. Not offered in 2013-2014.

Review of principles of the mechanisms of organic photochemical reactions.

CHEM G8314y. Molecular Recognition and Self-Assembly. 2.5 pts. Not offered in 2013-2014.

The chemistry of designing, synthesizing, and studying molecules that self-assemble.

CHEM G8316y. Supramolecular Chemistry. 2.5 pts. Prerequisites:G4147 or permission from the instructor.

Intermolecular interactions are at the structure-reactivity and structure-function relations of many issues in material sciences and biological chemistry. This course will describe the fundamental concepts and methodologies of the field and review its development over the past several decades. Emphasis will be placed on guest-host systems which can be developed based on the paradigm of the chemistry of enzymes.

CHEM G4071x. Inorganic Chemistry. 4.5 pts. Prerequisites:C3443-C3444 or C3045-C3046 Corequisites: N/A

Principles governing the structure and reactivity of inorganic compounds surveyed from experimental and theoretical viewpoints. Topics include inorganic solids, aqueous and nonaqueous solutions, the chemistry of selected main group elements, transition metal chemistry, metal clusters, metal carbonyls, and organometallic chemistry.

CHEM G4103y. Organometallic Chemistry. 4.5 pts. Prerequisites: Elementary organic chemistry. (Some background in inorganic and physical chemistry is helpful but not required.)

Main group and transition metal organometallic chemistry: bonding, structure, reactions, kinetics, and mechanisms.

CHEM G8104y. Structure Determination in Inorganic Chemistry. 2.5 pts. Not offered in 2013-2014.

The determination of structures by diffraction methods, focusing on single crystal X-ray diffraction, is described. Emphasis is placed on a critical evaluation of published data.

CHEM G8105y. Bioinorganic Chemistry. 2.5 pts. Not offered in 2013-2014.

Coordination chemistry of proteins and nucleic acids and their synthetic analogs.

CHEM G8106y. Kinetics. 2.5 pts. Not offered in 2013-2014.

Kinetics and mechanisms of inorganic reactions.

CHEM G8107y. Physical Methods in Inorganic Chemistry. 2.5 pts. Not offered in 2013-2014.

Advanced topics in spectroscopic methods as applied to transition metal complexes.

CHEM G8108y. Group Theory. 2.5 pts. Not offered in 2013-2014.

Chemical applications of group theory: structure, bonding and spectroscopy. Ligand field and molecular orbital theories.

CHEM G8110x. Applications of Transition-Metal Organometallics to Polymer Chemistry. 2.5 pts. Not offered in 2013-2014.

The use of transition-metal complexes as catalysts for olefin polymerization, and for atom transfer and chain transfer during free-radical polymerizations.

CHEM G8111y. Applications of NMR Spectroscopy to Inorganic Chemistry. 2.5 pts.

The use of multinuclear NMR spectroscopy in the determination of the structures of inorganic molecules and the use of dynamic NMR spectroscopy (variable temperature NMR and magnetization transfer techniques) to provide information concerned with reaction mechanisms.

CHEM G8130x. The Chemistry of Nanocrystals. 2.5 pts. Not offered in 2013-2014.

This course will provide a discussion of the thermodynamics and kinetics of colloidal crystallization and stabilization, the physical properties of quantum confined semiconductor and metal nanocrystals, methods of nanocrystal characterization, and examples of nanocrystals in technological applications. Prospective students should be familiar with basic principles of quantum mechanics, thermodynamics of phase transitions, and inorganic chemistry - particularly molecular orbital theory. Undergraduate students interested in this course should obtain approval from the instructor prior to registering.

CHEM G4221x. Quantum Chemistry. 4.5 pts. Prerequisites: Elementary physical chemistry.

Basic quantum mechanics: the Schrodinger equation and its interpretation, exact solutions in simple cases, methods or approximation, angular Mementum and electronic spin, and an introduction to atomic and molecular structure.

CHEM G4230x. Statistical Thermodynamics.. 4.5 pts. Prerequisites: Elementary physical chemistry. Corequisites:CHEM G4221

Topics include the classical and quantum statistical mechanics of gases, liquids, and solids.

CHEM G4232y. Introduction to Molecular Modeling. 4.5 pts. Prerequisites: Physical chemistry sequence.

Molecular modeling has become an integral part of research in many areas of chemistry, and in industry in drug discovery and materials design. Many experimental papers in the literature are routinely complemented by molecular modeling calculations. Experimental scientists working in industry have a significant advantage if they know how to optimally use modeling software. The course would consist of a normal lecture part plus a lab session every week in which the students learn to use modeling software by working on projects.Lab Required.

CHEM G6222y. Quantum Chemistry II. 2.5 pts. Prerequisites: Quantum Chemistry G4221

Atomic and molecular quantum mechanics: fundamentals of electronic structure, many-body wave functions and operators, Hartree-Fock and density functional theory, the Dirac equation.

CHEM G6231y. Intermediate Statistical Mechanics. 2.5 pts. Not offered in 2013-2014. Prerequisites: Chemistry G4221 and G4230

Phase transitions and critical phenomena; renormalization group methods; classical theory of fluids.

CHEM G6241y. Chemical Dynamics. 2.5 pts. Not offered in 2013-2014. Prerequisites: Chemistry G4221 or the equivalent.

Theory of the rates and temperature dependence of chemical reactions in gases and liquids.

CHEM G6242y. Interfaces and Condensed Phases. 2.5 pts. Not offered in 2013-2014. Prerequisites: Chemistry G4221 and G4230 or their equivalents.

Elements of the physical chemistry and electronic structure of interfaces and solid materials with application to organic conductors and semiconductors.

CHEM G6251y. Spectroscopy. 2.5 pts. Prerequisites: Chemistry G4221 or the equivalent.

Principles of the interaction of molecules with radiation. Applications of spectroscopy to elucidate molecular structure and bonding.

CHEM G8223y. Quantum Chemistry, III. 2.5 pts. Prerequisites: Chemistry G6222

Atomic and molecular quantum mechanics: electron correlation, configuration interaction, many-body perturbation theory, density functional methods.

CHEM G8232y. Advanced Statistical Mechanics. 2.5 pts. Prerequisites: Chemistry G4221 and G4230 or their equivalents.

Stochastic processes; Brownian motion; Langevin equations and fluctuation-dissipation theorems; reaction rate theory; time correlation functions and linear response theory.

CHEM G8252y. Special Topics in Physical Chemistry. 2.5 pts. Not offered in 2013-2014. Prerequisites: Chemistry G4221 or the equivalent.

Problems and methods in areas of current research interest.

This course does not count toward a concentration in chemistry.

BIOC G4026y. Biochemistry of Nucleic Acids and Protein Synthesis. 4.5 pts. Not offered in 2013-2014. Prerequisites:BCHM G4021, or the equivalent, BIOC C3501.

Structure and organization of chromatin, nucleic acid hybridization and sequence complexity of DNA, DNA and RNA sequencing methods, current views of replication and repair, transcription and translation, regulation of nucleic acid and protein synthesis, recombinant DNA techniqes, gene transfer and gene duplication. Discussion of original papers and evaluation of experimental procedures and conclusions.

CHEM G4137y. Photonics & Spectroscopy. 4.5 pts. Not offered in 2013-2014. Prerequisites: N/A Corequisites: N/A

Powerful photonics and spectroscopy tools are changing the way many physical and biological problems are addressed by revealing direct and precious energetic and dynamic information of molecular species inside live cells or novel materials. This full semester graduate course will not only provide fundamental knowledge of optics, laser, photonics, linear and nonlinear molecular spectroscopy, but also introduce physical principles of various emerging optical techniques including femotosecond spectroscopy, single-molecule spectroscopy, multi-photon nonlinear microscopy, label-free chemical imaging, super-resolution imaging, optical coherence tomography.Discussion Section Required.

BIOC G4170y. Biophysical Chemistry. 4.5 pts. Prerequisites: Elementary physical and organic chemistry.

Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance, analysis of the conformation of proteins and nucleic acids; hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

BIOC G8200x. Optical Bio-imaging. 2.5 pts. Not offered in 2013-2014.

Powerful optical imaging tools are changing the way many biological problems are addressed by revealing direct and precious visualization information inside live cells, tissues and organisms. This interdisciplinary course will not only provide fundamental knowledge of optics, laser, microscopy, linear and nonlinear molecular spectroscopy, but also introduce physical principles of various emerging microscopy techniques including single-molecule biophysics, multi-photon microscopy, label-free chemical imaging, super-resolution imaging, novel molecular probes, optical coherence tomography and emerging technology. A few guest lectures from expert instructors across the campus are expected.Discussion Section Required.

CHEM G8300y. Biophotonics. 2.5 pts.

Biophotonics tools are changing the way many biological problems are addressed by revealing direct and precious visualization information inside live cells, tissues and organisms. This interdisciplinary course will not only provide fundamental knowledge of optics, laser, microscopy, linear and nonlinear molecular spectroscopy, but also introduce physical principles of various emerging microscopy techniques including single-molecule biophysics, multi-photon microscopy, label-free chemical imaging, super-resolution imaging, novel molecular probes, optical coherence tomography and emerging technology. A few guest lectures from expert instructors across the campus are expected.